The paper at hand analyzes the relation between structural conditions and right-wing politically motivated crime across 16 German regions between 2002 and 2016. A first objective is to reveal the role of regional immigration rates by not only testing their main effect, but also considering their interaction with other problematic structural conditions. Including the recently introduced concept of a hostile and prejudiced social climate as potentially important structural condition is a second objective of the paper. Finally, the analyses are embedded in a quasi-experiment setting, because Germany witnessed a massive recent increase in immigration by refugees, to which is also publicly referred to as the “refugee crisis”. The model´s effects are compared between two samples offering the opportunity to explain right-wing hate crimes under different societal conditions of immigration influx. Several sets of negative binomial regression models with pooled cross-sectional time-series data gathered from official Federal German sources, as well as eight Rounds of the European Social Survey are calculated. The results reveal considerable differences in the comparable models of the different data sets and a more substantial relevance of the structural indicators during times of high immigration influx.